Areas of Expertise
- Pharmacokinetics, ADMET, drug interactions, pharmacogenetics, PBPK modelling
Research Projects
- Projects mainly related to drug interactions and pharmacokinetic modelling
Special Methodologies & Techniques
Major Funding & International Networks
Selected Publications
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Candesartan Has No Clinically Meaningful Effect on the Plasma Concentrations of Cytochrome P450 2C8 Substrate Repaglinide in Humans. Drug. Metab. Dispos. 2024. DOI: 10.1124/dmd.124.001798
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Hydroxychloroquine is Metabolized by Cytochrome P450 2D6, 3A4, and 2C8, and Inhibits Cytochrome P450 2D6, while its Metabolites also Inhibit Cytochrome P450 3A in vitro. Drug Metab Dispos. 2023. DOI: 10.1124/dmd.122.001018
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Translational aspects of cytochrome P450-mediated drug-drug interactions: A case study with clopidogrel. Basic Clin Pharmacol Toxicol 2022. DOI: 10.1111/bcpt.13647
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Comparative Hepatic and Intestinal Metabolism and Pharmacodynamics of Statins. Drug Metab Dispos. 2021. DOI: 10.1124/dmd.121.000406
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Improved predictions of time-dependent drug-drug interactions by determination of cytosolic drug concentrations. Sci Rep. 2019. DOI: 10.1038/s41598-019-42051-x
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