Areas of Expertise

• Post-translational modifications, ubiquitination in particular
• NF-κB signalling pathways
• Apoptotic and non-apoptotic roles of caspases
• Drosophila melanogaster as a model system

Research Projects

• Ubiquitination-mediated regulation of inflammation during cell stress and infection
• Targeting ubiquitin signalling in chronic inflammation and inflammation-induced cancer
• Ubiquitin-mediated control of starvation-induced intestinal inflammatory responses
• Caspase-mediated regulation of autophagy in inflammatory signalling
• Modulating caspase activation and immune signalling in intestinal inflammation

Special Methodologies & Techniques

• Analysis of ubiquitin modifications in vitro and in vivo
• Drosophila melanogaster as a model system to study cell signalling and immune responses
• Imaging caspase activation in vivo

Major Funding & International Networks

• InFLAMES Flagship
• Sigrid Jusélius Foundation
• Swedish Cultural Foundation
• COST Action CA20113/ProteoCure
• International Society of Protein Termini

Selected Publications

• Ubiquitin signalling in Drosophila innate immune responses. FEBS J. 2024. DOI: 10.1111/febs.17028
• Drosophila caspases as guardians of host-microbe interactions. Cell Death Differ. 2023. DOI: 10.1038/s41418-022-01038-4
• Core@shell structured ceria@mesoporous silica nanoantibiotics restrain bacterial growth in vitro and in vivo. Biomater. Adv. 2022. DOI: 10.1016/j.msec.2021.112607
• A M1-ubiquitination facilitates NF-kappaB activation and survival during sterile inflammation. FEBS J. 2022. DOI: 10.1111/febs.16425
• Drice restrains Diap2-mediated inflammatory signalling and intestinal inflammation. Cell Death Differ. 2022. DOI: 10.1038/s41418-021-00832-w

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