Areas of Expertise
- Cancer cell biology
- Cell adhesion and migration
- Microscopy and live imaging
- Image analysis
Research Projects
- The role of filopodia during breast cancer progression
- Cancer cell communication via filopodia trans- endocytosis
- Deciphering the mechanisms of pancreatic cancer metastasis
- The role of mechanosensitive calcium channels in melanoma
- The role of TLNRD1 in endothelium homeostasis
- Democratising deep learning for microscopy with ZeroCostDL4Mic
Special Methodologies & Techniques
- Microscopy (super-resolution microscopy, live imaging, traction force microscopy)
- Image analysis, deep learning, and computer vision
- Cell and molecular biology
- Mass spectrometry (identification of protein-protein interactions using pull-downs and biotinylation-based strategy)
- Zebrafish embryo to study cancer biology
- Flow and perfusion chambers
Major Funding & International Networks
- Sigrid Juselius Foundation
- Wellcome Trust
- Academy of Finland
- Finnish Cancer Foundation
- Inflames
- Turku Bioscience
Selected Publications
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TLNRD1 is a CCM complex component and regulates endothelial barrier integrity. J Cell Biol. 2024. DOI: 10.1083/jcb.202310030
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CellTracksColab is a platform that enables compilation, analysis, and exploration of cell tracking data. PLOS Biol. 2024. DOI: 10.1371/journal.pbio.3002740
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MYO10-filopodia support basement membranes at preinvasive tumor boundaries. Dev Cell. 2022. DOI: 10.1016/j.devcel.2022.09.016
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TrackMate 7: Integrating state-of-the-art segmentation algorithms into tracking pipelines. Nat. Methods. 2022. DOI: 10.1038/s41592-022-01507-1
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Democratising Deep Learning for Microscopy with ZeroCostDL4Mic. Nat Commun. 2021. DOI: 10.1038/s41467-021-22518-0
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