Areas of Expertise
- Cell Differentiation
- Cell Stress
- Post-translational Modifications
- Proteostasis
- Transcriptional Gene Regulation
Research Projects
- HSF-NET: Functional networks regulated by heat shock factors in cell plasticity, Research Council of Finland 2023-27
- Proteostasis driven by HSFs in cell plasticity programs and cancer”, Sigrid Jusélius Foundation 2025-28
- Re-programming of gene and enhancer expression in cell differentiation and stress, Liv och Hälsa 2023-26
- Pharmacologic strategy for targeting the main oncoproteins and defense systems of HPV-driven cancers, Cancer Foundation Finland 2024-26, together with John E. Eriksson
Special Methodologies & Techniques
- ChIP-seq
- DNA-protein interaction in vivo and in vitro
- Proteomics
- PRO-seq and RNA-seq, including data analysis
Major Funding & International Networks
- HSF-NET: Functional networks regulated by heat shock factors in cell plasticity, Research Council of Finland 2023-27
- Proteostasis driven by HSFs in cell plasticity programs and cancer”, Sigrid Jusélius Foundation 2025-28
- Re-programming of gene and enhancer expression in cell differentiation and stress, Liv och Hälsa 2023-26
- Pharmacologic strategy for targeting the main oncoproteins and defense systems of HPV-driven cancers, Cancer Foundation Finland 2024-26, together with John E. Eriksson
Selected Publications
-
Nuclear talin-1 provides a bridge between cell adhesion and gene expression. iScience. 2025. DOI: 10.1016/j.isci.2025.111745
-
CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder. Nat Commun. 2022. DOI: 10.1038/s41467-022-34476-2
-
HSFs drive transcription of distinct genes and enhancers during oxidative stress and heat shock. Nucleic Acids Res. 2022. DOI: 10.1093/nar/gkac493
-
Stress-induced transcriptional memory accelerates promoter-proximal pause release and decelerates termination over mitotic divisions. Mol Cell. 2021. DOI: 10.1016/j.molcel.2021.03.007
-
Heat shock factor 2 protects against proteotoxicity by maintaining cell-cell adhesion. Cell Rep. 2020. DOI: 10.1016/j.celrep.2019.12.037
← Back to Portfolio
