Areas of Expertise

• Gene expression
• Chromatin remodelling
• Viral reactivation from latency
• Cellular transformation

Research Projects

• Role of somatic mutations in Epstein-Barr virus-induced oncogenesis and drug resistance
• Role of stress-related transcription factors in oncogenic herpesvirus persistence and gene expression
• New diagnostic tools based on DNA nanotechnology to detect viral genomic sequences

Special Methodologies & Techniques

• Patient-derived organoids
• Lentiviral production and transduction
• Chromatin IP
• Proteomics

Major Funding & International Networks

• Research Council of Finland
• Sigrid Juselius
• Finnish Cultural Foundation
• Mary & George Ehrnrooth Foundation
• Suomen Tiedeseura
• InFLAMES

Selected Publications

• Heat shock factor 2 regulates oncogenic gamma-herpesvirus gene expression by remodeling the chromatin at the ORF50 and BZLF1 promoter. PLoS Pathog. 2025. DOI: 10.1371/journal.ppat.1013108
• DLL4/Notch3/WNT5B axis mediates bidirectional prometastatic crosstalk between melanoma and lymphatic endothelial cells. JCI Insight. 2024. DOI: 10.1172/jci.insight.171821
• Oncogenic Herpesvirus Engages Endothelial Transcription Factors SOX18 and PROX1 to Increase Viral Genome Copies and Virus Production. Cancer Res. 2020. DOI: 10.1158/0008-5472.CAN-19-3103
• Kaposis Sarcoma-Associated Herpesvirus Lytic Replication Is Independent of Anaphase-Promoting Complex Activity. Journal of Virology. 2020. DOI: 10.1128/JVI.02079-19
• High tissue MMP14 expression predicts worse survival in gastric cancer, particularly with a low PROX1. Cancer Medicine. 2019. DOI: 10.1002/cam4.2576

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