Areas of Expertise

• Protein biochemistry, bioinformatics, and Structural biology
• Protein-ligand interactions
• Molecular interaction mechanisms in inflammation, infection, and cancer
• Disease-causing genetic variation
• Structure-based drug design
• Targeted diagnostics

Research Projects

• Selective treatments against Borrelia infections
• Immunosuppressive SEFIR protein asa target against Klebsiella infections
• Expanding toolbox for Clever-1-targeted oncotherapy
• Intercepting Siglec-9 interactions in cancer and inflammation
• Molecular mechanism of collagen-binding integrin activation

Special Methodologies & Techniques

• Modern facilities for protein purification and sample quality control
• State-of-the-art infrastructure for protein crystallization
• Automated imaging of protein crystallization trials
• In-situ diffraction testing
• Infrastructure for Cryo-electron microscopy sample preparation
• Up-to-date infrastructure for computational biology and Scientific IT Support

Major Funding & International Networks

• Research Council Finland
• InFLAMES Flagship
• Medicinska Understödsföreningen Liv och Hälsa rf
• Tor, Joe och Pentti Borg Foundation
• 3D-BioInfo Community of ELIXIR
• International Network of Protein Engineering Centres (INPEC)

Selected Publications

• Secreted Clever-1 modulates T cell responses and impacts cancer immunotherapy efficacy. Theranostics. 2025. DOI: 10.7150/thno.110544
• Apprehensions and emerging solutions in ML-based protein structure prediction. Curr. Opin. Struct. Biol. 2024. DOI: 10.1016/j.sbi.2024.102819
• Vascular adhesion protein-1-targeted PET imaging in autoimmune myocarditis. J. Nucl. Cardiol. 2023. DOI: 10.1007/s12350-023-03371-8
• Klebsiella pneumoniae type VI secretion system-mediated microbial competition is PhoPQ controlled and reactive oxygen species dependent. PloS Pathog. 2020. DOI: 10.1371/journal.ppat.1007969
• Structural and Biomolecular Analyses of Borrelia burgdorferi BmpD Reveal a Substrate-Binding Protein of an ABC-Type Nucleoside Transporter Family. Infect. Immun. 2020. DOI: 10.1128/IAI.00962-19

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